Rapid detection of an I38T amino acid substitution in influenza polymerase acidic subunit associated with reduced susceptibility to baloxavir marboxil

BACKGROUND: The novel cap‐dependent endonuclease inhibitor baloxavir marboxil was approved in February 2018 for the treatment of influenza virus infection in Japan. In vitro studies have revealed that an I38T substitution in the polymerase acidic subunit (PA) is associated with reduced susceptibilit...

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Dettagli Bibliografici
Pubblicato in:Influenza Other Respir Viruses
Autori principali: Nakauchi, Mina, Takashita, Emi, Fujisaki, Seiichiro, Shirakura, Masayuki, Ogawa, Rie, Morita, Hiroko, Miura, Hideka, Saito, Shinji, Watanabe, Shinji, Odagiri, Takato, Kageyama, Tsutomu
Natura: Artigo
Lingua:Inglês
Pubblicazione: John Wiley and Sons Inc. 2020
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Original Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7298299/
https://ncbi.nlm.nih.gov/pubmed/32064779
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/irv.12728
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