Rapid detection of an I38T amino acid substitution in influenza polymerase acidic subunit associated with reduced susceptibility to baloxavir marboxil

BACKGROUND: The novel cap‐dependent endonuclease inhibitor baloxavir marboxil was approved in February 2018 for the treatment of influenza virus infection in Japan. In vitro studies have revealed that an I38T substitution in the polymerase acidic subunit (PA) is associated with reduced susceptibilit...

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Detalhes bibliográficos
Publicado no:Influenza Other Respir Viruses
Main Authors: Nakauchi, Mina, Takashita, Emi, Fujisaki, Seiichiro, Shirakura, Masayuki, Ogawa, Rie, Morita, Hiroko, Miura, Hideka, Saito, Shinji, Watanabe, Shinji, Odagiri, Takato, Kageyama, Tsutomu
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2020
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Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7298299/
https://ncbi.nlm.nih.gov/pubmed/32064779
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/irv.12728
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