JAK inhibitors impair GM-CSF-mediated signaling in innate immune cells

BACKGROUND: Innate immune cells play a crucial role in the pathophysiology of rheumatoid arthritis (RA) via release of cytokines. Small-molecule inhibitors of Janus kinases (JAKi) are clinically efficacious in patients with RA. However, the isoform-specific action of each JAKi is difficult to assess...

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Detalhes bibliográficos
Publicado no:BMC Immunol
Main Authors: Fujita, Yuya, Matsuoka, Naoki, Temmoku, Jumpei, Furuya-Yashiro, Makiko, Asano, Tomoyuki, Sato, Shuzo, Matsumoto, Haruki, Watanabe, Hiroshi, Kozuru, Hideko, Yatsuhashi, Hiroshi, Kawakami, Atsushi, Migita, Kiyoshi
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2020
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7296727/
https://ncbi.nlm.nih.gov/pubmed/32539713
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12865-020-00365-w
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