Hydroxychloroquine inhibits IL-1β production from amyloid-stimulated human neutrophils

BACKGROUND: Hydroxychloroquine (HCQ) is used for the treatment of patients with rheumatic diseases. We tested the hypothesis that HCQ affects the NLRP3 inflammasome, which is involved in autoinflammation. METHODS: Human neutrophils were stimulated with serum amyloid A (SAA) in vitro and measured for...

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Detalhes bibliográficos
Publicado no:Arthritis Res Ther
Main Authors: Fujita, Yuya, Matsuoka, Naoki, Temmoku, Jumpei, Furuya, Makiko Yashiro, Asano, Tomoyuki, Sato, Shuzo, Kobayashi, Hiroko, Watanabe, Hiroshi, Suzuki, Eiji, Urano, Takeshi, Kozuru, Hideko, Yatsuhashi, Hiroshi, Koga, Tomohiro, Kawakami, Atsushi, Migita, Kiyoshi
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2019
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6880583/
https://ncbi.nlm.nih.gov/pubmed/31775905
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13075-019-2040-6
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