Hydroxychloroquine inhibits IL-1β production from amyloid-stimulated human neutrophils

Abstract Background Hydroxychloroquine (HCQ) is used for the treatment of patients with rheumatic diseases. We tested the hypothesis that HCQ affects the NLRP3 inflammasome, which is involved in autoinflammation. Methods Human neutrophils were stimulated with serum amyloid A (SAA) in vitro and measu...

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Main Authors: Yuya Fujita, Naoki Matsuoka, Jumpei Temmoku, Makiko Yashiro Furuya, Tomoyuki Asano, Shuzo Sato, Hiroko Kobayashi, Hiroshi Watanabe, Eiji Suzuki, Takeshi Urano, Hideko Kozuru, Hiroshi Yatsuhashi, Tomohiro Koga, Atsushi Kawakami, Kiyoshi Migita
格式: Artigo
語言:Inglês
出版: BMC 2019-11-01
叢編:Arthritis Research & Therapy
主題:
Amyloid
Hydroxychloroquine
Inflammasome
Interleukin-1 beta
Neutrophils
NLR family pyrin domain containing 3
在線閱讀:http://link.springer.com/article/10.1186/s13075-019-2040-6
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