Small Molecule Carboxylates Inhibit Metallo-β-lactamases and Resensitize Carbapenem-Resistant Bacteria to Meropenem

[Image: see text] In the search for new inhibitors of bacterial metallo-β-lactamases (MBLs), a series of commonly used small molecule carboxylic acid derivatives were evaluated for their ability to inhibit New Delhi metallo-β-lactamase (NDM)-, Verona integron-encoded metallo-β-lactamase (VIM)-, and...

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Publicat a:ACS Infect Dis
Autors principals: Tehrani, Kamaleddin H. M. E., Brüchle, Nora C., Wade, Nicola, Mashayekhi, Vida, Pesce, Diego, van Haren, Matthijs J., Martin, Nathaniel I.
Format: Artigo
Idioma:Inglês
Publicat: American Chemical Society 2020
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7296533/
https://ncbi.nlm.nih.gov/pubmed/32227874
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsinfecdis.9b00459
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