Dysregulation of Lipid Metabolism in Macrophages Is Responsible for Severe Endotoxin Tolerance in FcgRIIB-Deficient Lupus Mice

FcgRIIB dysfunction is commonly found in patients with lupus, especially in Asia. LPS-tolerance is prominent in FcgRIIB–/– lupus mice. LPS-tolerant macrophages demonstrate cell energy depletion, which might affect lipid metabolism. Therefore, to explore lipid metabolism, LPS-tolerance was induced tw...

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Détails bibliographiques
Publié dans:Front Immunol
Auteurs principaux: Jaroonwitchawan, Thiranut, Visitchanakun, Peerapat, Dang, Phi Cong, Ritprajak, Patcharee, Palaga, Tanapat, Leelahavanichkul, Asada
Format: Artigo
Langue:Inglês
Publié: Frontiers Media S.A. 2020
Sujets:
Immunology
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7296175/
https://ncbi.nlm.nih.gov/pubmed/32582149
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2020.00959
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