Syk Inhibitor Attenuates Polymicrobial Sepsis in FcgRIIb-Deficient Lupus Mouse Model, the Impact of Lupus Characteristics in Sepsis

The impact of spleen tyrosine kinase (Syk) signaling might be prominent in lupus because (i) Syk is a shared downstream signaling molecule among circulating immune complex, LPS, and (1→3)-β-D-glucan (BG), and (ii) all of these factors are detectable in the serum of Fc gamma receptor IIb-deficient (F...

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Bibliografiska uppgifter
I publikationen:J Innate Immun
Huvudupphovsmän: Issara-Amphorn, Jiraphorn, Chancharoenthana, Wiwat, Visitchanakun, Peerapat, Leelahavanichkul, Asada
Materialtyp: Artigo
Språk:Inglês
Publicerad: S. Karger AG 2020
Ämnen:
Research Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC7747092/
https://ncbi.nlm.nih.gov/pubmed/32927460
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1159/000509111
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