Shikonin Inhibits Cancer Through P21 Upregulation and Apoptosis Induction

Shikonin is a natural naphthoquinone compound and has demonstrated potent anti-cancer activities; however, the underlying molecular mechanisms remained elusive. Here we report that Shikonin inhibited the growth of a wide range of human cancer cell lines, illustrating a broad anticancer effect. Mecha...

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Bibliographic Details
Published in:Front Pharmacol
Main Authors: Wang, Fangfang, Mayca Pozo, Franklin, Tian, Danmei, Geng, Xinran, Yao, Xinsheng, Zhang, Youwei, Tang, Jinshan
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2020
Subjects:
Pharmacology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7296065/
https://ncbi.nlm.nih.gov/pubmed/32581812
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2020.00861
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