Regulatory cross-talk determines the cellular levels of 53BP1 protein, a critical factor in DNA repair

DNA double strand breaks (DSBs) severely disrupt DNA integrity. 53BP1 plays critical roles in determining DSB repair. Whereas the recruitment of 53BP1 to the DSB site is key for its function, recent evidence suggests that 53BP1's abundance also plays an important role in DSB repair because recr...

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Библиографические подробности
Опубликовано в: :J Biol Chem
Главные авторы: Mayca Pozo, Franklin, Tang, Jinshan, Bonk, Kristen W., Keri, Ruth A., Yao, Xinsheng, Zhang, Youwei
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Biochemistry and Molecular Biology 2017
Предметы:
DNA and Chromosomes
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5392589/
https://ncbi.nlm.nih.gov/pubmed/28255090
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.760645
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