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Inferring protein 3D structure from deep mutation scans
We describe an experimental method of three-dimensional (3D) structure determination that exploits the increasing ease of high-throughput mutational scans. Inspired by the success of using natural, evolutionary sequence co-variation to compute protein and RNA folds, we explored whether ‘laboratory’,...
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| Publicado no: | Nat Genet |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7295002/ https://ncbi.nlm.nih.gov/pubmed/31209393 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41588-019-0432-9 |
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