Functional proteomics interrogation of the kinome identifies MRCKA as a therapeutic target in high-grade serous ovarian carcinoma

High-grade serous ovarian carcinoma (HGSOC) is the most lethal gynecological cancer with few effective, targeted therapies. HGSOC tumors exhibit genomic instability with frequent alterations in the protein kinome; however, only a small fraction of the kinome has been therapeutically targeted in HGSO...

Полное описание

Сохранить в:
Библиографические подробности
Опубликовано в: :Sci Signal
Главные авторы: Kurimchak, Alison M., Herrera-Montavez, Carlos, Brown, Jennifer, Johnson, Katherine J., Sodi, Valerie, Srivastava, Nishi, Kumar, Vikas, Deihimi, Safoora, O’Brien, Shane, Peri, Suraj, Mantia-Smaldone, Gina M., Jain, Angela, Winters, Ryan M., Cai, Kathy Q., Chernoff, Jonathan, Connolly, Denise C., Duncan, James S.
Формат: Artigo
Язык:Inglês
Опубликовано: 2020
Предметы:
Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC7294993/
https://ncbi.nlm.nih.gov/pubmed/32071169
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.aax8238
Метки: Добавить метку
Нет меток, Требуется 1-ая метка записи!

Схожие документы