Functional proteomics interrogation of the kinome identifies MRCKA as a therapeutic target in high-grade serous ovarian carcinoma

High-grade serous ovarian carcinoma (HGSOC) is the most lethal gynecological cancer with few effective, targeted therapies. HGSOC tumors exhibit genomic instability with frequent alterations in the protein kinome; however, only a small fraction of the kinome has been therapeutically targeted in HGSO...

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Detalhes bibliográficos
Publicado no:Sci Signal
Main Authors: Kurimchak, Alison M., Herrera-Montavez, Carlos, Brown, Jennifer, Johnson, Katherine J., Sodi, Valerie, Srivastava, Nishi, Kumar, Vikas, Deihimi, Safoora, O’Brien, Shane, Peri, Suraj, Mantia-Smaldone, Gina M., Jain, Angela, Winters, Ryan M., Cai, Kathy Q., Chernoff, Jonathan, Connolly, Denise C., Duncan, James S.
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7294993/
https://ncbi.nlm.nih.gov/pubmed/32071169
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.aax8238
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