S1P promotes IL-6 expression in osteoblasts through the PI3K, MEK/ERK and NF-κB signaling pathways

Rheumatoid arthritis (RA) is a systemic autoimmune inflammatory disease, in which the immune system attacks joint tissue. Interleukin (IL)-6 is a key proinflammatory cytokine in RA progression. Sphingosine-1-phosphate (S1P), a platelet-derived lysophospholipid mediator, reportedly regulates osteoimm...

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Detalhes bibliográficos
Publicado no:Int J Med Sci
Main Authors: Hu, Sung-Lin, Huang, Chien-Chung, Tzeng, Tzu-Ting, Liu, Shan-Chi, Tsai, Chun-Hao, Fong, Yi-Chin, Tang, Chih-Hsin
Formato: Artigo
Idioma:Inglês
Publicado em: Ivyspring International Publisher 2020
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7294913/
https://ncbi.nlm.nih.gov/pubmed/32547316
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7150/ijms.44612
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