CRISPR-Cas9 Ribonucleoprotein-Mediated Genomic Editing in Mature Primary Innate Immune Cells

CRISPR genome engineering has become a powerful tool to functionally investigate the complex mechanisms of immune system regulation. While decades of work have aimed to genetically reprogram innate immunity, the utility of current approaches is restricted by poor knockout efficiencies or limited spe...

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Veröffentlicht in:Cell Rep
Hauptverfasser: Riggan, Luke, Hildreth, Andrew D., Rolot, Marion, Wong, Yung-Yu, Satyadi, William, Sun, Ryan, Huerta, Christopher, O’Sullivan, Timothy E.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2020
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7294876/
https://ncbi.nlm.nih.gov/pubmed/32433960
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2020.107651
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