Discovery of 2,6-Dimethylpiperazines as Allosteric Inhibitors of CPS1

[Image: see text] Carbamoyl phosphate synthetase 1 (CPS1) is a potential synthetic lethal target in LKB1-deficient nonsmall cell lung cancer, where its overexpression supports the production of pyrimidine synthesis. In other cancer types, CPS1 overexpression and activity may prevent the accumulation...

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Detalhes bibliográficos
Publicado no:ACS Med Chem Lett
Main Authors: Rolfe, Alan, Yao, Shihua, Nguyen, Toung-Vi, Omoto, Kiyoyuki, Colombo, Federico, Virrankoski, Milena, Vaillancourt, Frédéric H., Yu, Lihua, Cook, Andrew, Reynolds, Dominic, Ioannidis, Stephanos, Zhu, Ping, Larsen, Nicholas A., Bolduc, David M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2020
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7294722/
https://ncbi.nlm.nih.gov/pubmed/32551016
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.0c00145
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