Structure-Guided Optimization of Replication Protein A (RPA)–DNA Interaction Inhibitors

[Image: see text] Replication protein A (RPA) is the major human single stranded DNA (ssDNA)-binding protein, playing essential roles in DNA replication, repair, recombination, and DNA-damage response (DDR). Inhibition of RPA–DNA interactions represents a therapeutic strategy for cancer drug discove...

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Bibliografiset tiedot
Julkaisussa:ACS Med Chem Lett
Päätekijät: Gavande, Navnath S., VanderVere-Carozza, Pamela S., Pawelczak, Katherine S., Vernon, Tyler L., Jordan, Matthew R., Turchi, John J.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: American Chemical Society 2020
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC7294550/
https://ncbi.nlm.nih.gov/pubmed/32550990
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.9b00440
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