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Structure-Guided Optimization of Replication Protein A (RPA)–DNA Interaction Inhibitors
[Image: see text] Replication protein A (RPA) is the major human single stranded DNA (ssDNA)-binding protein, playing essential roles in DNA replication, repair, recombination, and DNA-damage response (DDR). Inhibition of RPA–DNA interactions represents a therapeutic strategy for cancer drug discove...
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| Publicat a: | ACS Med Chem Lett |
|---|---|
| Autors principals: | , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
American Chemical
Society
2020
|
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7294550/ https://ncbi.nlm.nih.gov/pubmed/32550990 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.9b00440 |
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