Gene knockout of the Na(+)-glucose cotransporter SGLT2 in a murine model of acute kidney injury induced by ischemia-reperfusion

In the early proximal tubule, Na(+)-glucose cotransporter 2 (SGLT2) mediates the bulk of renal glucose reabsorption. Gene deletion in mice (Sglt2(−/−)) was used to determine the role of SGLT2 in acute kidney injury induced by bilateral ischemia-reperfusion (IR). In Sglt2(−/−) and littermate wild-typ...

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Detaylı Bibliyografya
Yayımlandı:Am J Physiol Renal Physiol
Asıl Yazarlar: Nespoux, Josselin, Patel, Rohit, Zhang, Haiyan, Huang, Winnie, Freeman, Brent, Sanders, Paul W., Kim, Young Chul, Vallon, Volker
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Physiological Society 2020
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC7294332/
https://ncbi.nlm.nih.gov/pubmed/32116018
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajprenal.00607.2019
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