Gene deletion of the Na(+)-glucose cotransporter SGLT1 ameliorates kidney recovery in a murine model of acute kidney injury induced by ischemia-reperfusion

Renal Na(+)-glucose cotransporter SGLT1 mediates glucose reabsorption in the late proximal tubule, a hypoxia-sensitive tubular segment that enters the outer medulla. Gene deletion in mice (Sglt1(−/−)) was used to determine the role of the cotransporter in acute kidney injury induced by ischemia-repe...

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Опубликовано в: :Am J Physiol Renal Physiol
Главные авторы: Nespoux, Josselin, Patel, Rohit, Hudkins, Kelly L., Huang, Winnie, Freeman, Brent, Kim, Young Chul, Koepsell, Hermann, Alpers, Charles E., Vallon, Volker
Формат: Artigo
Язык:Inglês
Опубликовано: American Physiological Society 2019
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Research Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC6620597/
https://ncbi.nlm.nih.gov/pubmed/30995111
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajprenal.00111.2019
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