Smad2/3‐pathway ligand trap luspatercept enhances erythroid differentiation in murine β‐thalassaemia by increasing GATA‐1 availability

In β‐thalassaemia, anaemia results from ineffective erythropoiesis characterized by inhibition of late‐stage erythroid differentiation. We earlier used luspatercept and RAP‐536 protein traps for certain Smad2/3‐pathway ligands to implicate Smad2/3‐pathway overactivation in dysregulated erythroid dif...

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Detalhes bibliográficos
Publicado no:J Cell Mol Med
Main Authors: Martinez, Pedro A., Li, Robert, Ramanathan, Harish N., Bhasin, Manoj, Pearsall, R. Scott, Kumar, Ravindra, Suragani, Rajasekhar N. V. S.
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2020
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7294138/
https://ncbi.nlm.nih.gov/pubmed/32351032
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/jcmm.15243
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