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Biological basis for efficacy of activin receptor ligand traps in myelodysplastic syndromes
Signaling by the TGF-β superfamily is important in the regulation of hematopoiesis and is dysregulated in myelodysplastic syndromes (MDSs), contributing to ineffective hematopoiesis and clinical cytopenias. TGF-β, activins, and growth differentiation factors exert inhibitory effects on red cell form...
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| Publié dans: | J Clin Invest |
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| Auteurs principaux: | , , , , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
American Society for Clinical Investigation
2020
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6994157/ https://ncbi.nlm.nih.gov/pubmed/31961337 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI133678 |
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