The Zα2 domain of ZBP1 is a molecular switch regulating influenza-induced PANoptosis and perinatal lethality during development

Z-DNA-binding protein 1 (ZBP1) is an innate immune sensor of nucleic acids that regulates host defense responses and development. ZBP1 activation triggers inflammation and pyroptosis, necroptosis, and apoptosis (PANoptosis) by activating receptor-interacting Ser/Thr kinase 3 (RIPK3), caspase-8, and...

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Bibliographic Details
Published in:J Biol Chem
Main Authors: Kesavardhana, Sannula, Malireddi, R. K. Subbarao, Burton, Amanda R., Porter, Shaina N., Vogel, Peter, Pruett-Miller, Shondra M., Kanneganti, Thirumala-Devi
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2020
Subjects:
Microbiology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7294087/
https://ncbi.nlm.nih.gov/pubmed/32350114
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA120.013752
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