The structure of the extracellular domains of human interleukin 11α receptor reveals mechanisms of cytokine engagement

Interleukin (IL) 11 activates multiple intracellular signaling pathways by forming a complex with its cell surface α-receptor, IL-11Rα, and the β-subunit receptor, gp130. Dysregulated IL-11 signaling has been implicated in several diseases, including some cancers and fibrosis. Mutations in IL-11Rα t...

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Udgivet i:J Biol Chem
Main Authors: Metcalfe, Riley D., Aizel, Kaheina, Zlatic, Courtney O., Nguyen, Paul M., Morton, Craig J., Lio, Daisy Sio-Seng, Cheng, Heung-Chin, Dobson, Renwick C. J., Parker, Michael W., Gooley, Paul R., Putoczki, Tracy L., Griffin, Michael D. W.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2020
Fag:
Protein Structure and Folding
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7294085/
https://ncbi.nlm.nih.gov/pubmed/32332100
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.012351
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