Cytochrome P4501B1 in bone marrow is co-expressed with key markers of mesenchymal stem cells. BMS2 cell line models PAH disruption of bone marrow niche development functions

Polycyclic aromatic hydrocarbons (PAHs) are ubiquitous pollutants that are metabolized to carcinogenic dihydrodiol epoxides (PAHDE) by cytochrome P450 1B1 (CYP1B1). This metabolism occurs in bone marrow (BM) mesenchymal stem cells (MSC), which sustain hematopoietic stem and progenitor cells (HSPC)....

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Bibliografiset tiedot
Julkaisussa:Toxicol Appl Pharmacol
Päätekijät: Larsen, Michele Campaigne, Almeldin, Ahmed, Tong, Tiegang, Rondelli, Catherine M., Maguire, Meghan, Jaskula-Sztul, Renata, Jefcoate, Colin R.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Published by Elsevier Inc. 2020
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Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC7293885/
https://ncbi.nlm.nih.gov/pubmed/32553695
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.taap.2020.115111
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