Cytochrome P4501B1 in bone marrow is co-expressed with key markers of mesenchymal stem cells. BMS2 cell line models PAH disruption of bone marrow niche development functions

Polycyclic aromatic hydrocarbons (PAHs) are ubiquitous pollutants that are metabolized to carcinogenic dihydrodiol epoxides (PAHDE) by cytochrome P450 1B1 (CYP1B1). This metabolism occurs in bone marrow (BM) mesenchymal stem cells (MSC), which sustain hematopoietic stem and progenitor cells (HSPC)....

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Bibliographic Details
Published in:Toxicol Appl Pharmacol
Main Authors: Larsen, Michele Campaigne, Almeldin, Ahmed, Tong, Tiegang, Rondelli, Catherine M., Maguire, Meghan, Jaskula-Sztul, Renata, Jefcoate, Colin R.
Format: Artigo
Language:Inglês
Published: Published by Elsevier Inc. 2020
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7293885/
https://ncbi.nlm.nih.gov/pubmed/32553695
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.taap.2020.115111
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