PAHs Target Hematopoietic Linages in Bone Marrow through Cyp1b1 Primarily in Mesenchymal Stromal Cells but Not AhR: A Reconstituted In Vitro Model

7,12-Dimethylbenz(a)anthracene (DMBA) rapidly suppresses hematopoietic progenitors, measured as colony forming units (CFU), in mouse bone marrow (BM) leading to mature cell losses as replenishment fails. These losses are mediated by Cyp1b1, independent of the AhR, despite induction of Cyp1b1. BM mes...

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Vydáno v:Stem Cells Int
Hlavní autoři: Rondelli, Catherine M., Larsen, Michele Campaigne, N'jai, Alhaji, Czuprynski, Charles J., Jefcoate, Colin R.
Médium: Artigo
Jazyk:Inglês
Vydáno: Hindawi Publishing Corporation 2016
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5116507/
https://ncbi.nlm.nih.gov/pubmed/27891153
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2016/1753491
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