PAHs Target Hematopoietic Linages in Bone Marrow through Cyp1b1 Primarily in Mesenchymal Stromal Cells but Not AhR: A Reconstituted In Vitro Model

7,12-Dimethylbenz(a)anthracene (DMBA) rapidly suppresses hematopoietic progenitors, measured as colony forming units (CFU), in mouse bone marrow (BM) leading to mature cell losses as replenishment fails. These losses are mediated by Cyp1b1, independent of the AhR, despite induction of Cyp1b1. BM mes...

Полное описание

Сохранить в:
Библиографические подробности
Опубликовано в: :Stem Cells Int
Главные авторы: Rondelli, Catherine M., Larsen, Michele Campaigne, N'jai, Alhaji, Czuprynski, Charles J., Jefcoate, Colin R.
Формат: Artigo
Язык:Inglês
Опубликовано: Hindawi Publishing Corporation 2016
Предметы:
Research Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5116507/
https://ncbi.nlm.nih.gov/pubmed/27891153
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2016/1753491
Метки: Добавить метку
Нет меток, Требуется 1-ая метка записи!

Схожие документы