Cyp1b1‐mediated suppression of lymphoid progenitors in bone marrow by polycyclic aromatic hydrocarbons coordinately impacts spleen and thymus: a selective role for the Ah Receptor

Bone marrow (BM) hematopoietic stem cells differentiate to common lymphoid progenitors (CLP) that emigrate to the thymus to form T cells or differentiate into immature B cells that then migrate to the spleen for maturation. Rapid in vivo suppression of BM progenitor cells by a single oral or intrape...

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Detalhes bibliográficos
Publicado no:Pharmacol Res Perspect
Main Authors: Larsen, Michele Campaigne, N'Jai, Alhaji U., Alexander, David L., Rondelli, Catherine M., Forsberg, E C., Czuprynski, Charles J., Jefcoate, Colin R.
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2016
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5242170/
https://ncbi.nlm.nih.gov/pubmed/28116098
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/prp2.245
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