Forward genetic analysis using OCT screening identifies Sfxn3 mutations leading to progressive outer retinal degeneration in mice

Retinal disease and loss of vision can result from any disruption of the complex pathways controlling retinal development and homeostasis. Forward genetics provides an excellent tool to find, in an unbiased manner, genes that are essential to these processes. Using N-ethyl-N-nitrosourea mutagenesis...

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Vydáno v:Proc Natl Acad Sci U S A
Hlavní autoři: Chen, Bo, Aredo, Bogale, Ding, Yi, Zhong, Xin, Zhu, Yuanfei, Zhao, Cynthia X., Kumar, Ashwani, Xing, Chao, Gautron, Laurent, Lyon, Stephen, Russell, Jamie, Li, Xiaohong, Tang, Miao, Anderton, Priscilla, Ludwig, Sara, Moresco, Eva Marie Y., Beutler, Bruce, Ufret-Vincenty, Rafael L.
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2020
Témata:
Biological Sciences
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7293615/
https://ncbi.nlm.nih.gov/pubmed/32457148
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1921224117
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