Utility of the DHFR-based destabilizing domain across mouse models of retinal degeneration and aging

Summary: The Escherichia coli dihydrofolate reductase (DHFR) destabilizing domain (DD) serves as a promising approach to conditionally regulate protein abundance in a variety of tissues. To test whether this approach could be effectively applied to a wide variety of aged and disease-related ocular m...

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Main Authors: Hui Peng, Prerana Ramadurgum, DaNae R. Woodard, Steffi Daniel, Emi Nakahara, Marian Renwick, Bogale Aredo, Shyamtanu Datta, Bo Chen, Rafael Ufret-Vincenty, John D. Hulleman
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2022-05-01
Colecção:iScience
Assuntos:
Medicine
Therapeutics
Molecular biology
Cell biology
Acesso em linha:http://www.sciencedirect.com/science/article/pii/S258900422200476X
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