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Quantification of ongoing APOBEC3A activity in tumor cells by monitoring RNA editing at hotspots
APOBEC3A is a cytidine deaminase driving mutagenesis, DNA replication stress and DNA damage in cancer cells. While the APOBEC3A-induced vulnerability of cancers offers an opportunity for therapy, APOBEC3A protein and mRNA are difficult to quantify in tumors due to their low abundance. Here, we descr...
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| 出版年: | Nat Commun |
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| 主要な著者: | , , , , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Nature Publishing Group UK
2020
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7293259/ https://ncbi.nlm.nih.gov/pubmed/32532990 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-16802-8 |
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