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Generation of a stand-alone tryptophan synthase α-subunit by mimicking an evolutionary blueprint

The αββα tryptophan synthase (TS), which is part of primary metabolism, is a paradigm for allosteric communication in multi-enzyme complexes. In particular, the intrinsically low catalytic activity of the α-subunit TrpA is stimulated several hundred-fold by the interaction with the β-subunit TrpB1....

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Chembiochem
Prif Awduron: Schupfner, Michael, Busch, Florian, Wysocki, Vicki H., Sterner, Reinhard
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2019
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC7293203/
https://ncbi.nlm.nih.gov/pubmed/31090986
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cbic.201900323
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