In silico and in vitro identification of secoisolariciresinol as a re-sensitizer of P-glycoprotein-dependent doxorubicin-resistance NCI/ADR-RES cancer cells

P-glycoprotein (P-gp) is one of the highly expressed cancer cell efflux transporters that cause the failure of chemotherapy. To reverse P-gp induced multidrug resistance, we employed a flaxseed-derived lignan; secoisolariciresinol (SECO) that acts as an inhibitor of breast cancer resistance protein;...

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Publicat a:PeerJ
Autors principals: Morsy, Mohamed A., El-Sheikh, Azza A.K., Ibrahim, Ahmed R.N., Venugopala, Katharigatta N., Kandeel, Mahmoud
Format: Artigo
Idioma:Inglês
Publicat: PeerJ Inc. 2020
Matèries:
Bioinformatics
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7293189/
https://ncbi.nlm.nih.gov/pubmed/32566390
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7717/peerj.9163
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