Targeting of micelles and liposomes loaded with the pro-apoptotic drug, NCL-240, into NCI/ADR-RES cells in a 3D spheroid model

PURPOSE: To develop transferrin (Tf)-targeted delivery systems for the pro-apoptotic drug, NCL-240, and to evaluate the efficacy of this delivery system in ovarian cancer NCI/ADR-RES cells, grown in vitro in a 3D spheroid model. METHODS: Tf-targeted PEG-PE-based micellar and ePC/CHOL-based liposomal...

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Publicado no:Pharm Res
Main Authors: Pattni, Bhushan S., Nagelli, Srikar G., Aryasomayajula, Bhawani, Deshpande, Pranali P., Kulkarni, Abhijit, Hartner, William C., Thakur, Ganesh, Degterev, Alexei, Torchilin, Vladimir P.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5007212/
https://ncbi.nlm.nih.gov/pubmed/27351426
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11095-016-1978-1
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