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Cytotoxicity of PEGylated Liposomes Co-Loaded with Novel Pro-Apoptotic Drug NCL-240 and the MEK Inhibitor Cobimetinib Against Colon Carcinoma In Vitro

The overactivation of signaling pathways, such as the PI3K and MAPK, which are crucial to cell growth and survival, is a common feature in many cancer types. Though a number of advances have been made in the development of molecular agents targeting these pathways, their application as monotherapies...

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Bibliografiske detaljer
Udgivet i:J Control Release
Main Authors: Sriraman, Shravan Kumar, Geraldo, Vananelia, Luther, Ed, Degterev, Alexei, Torchilin, Vladimir
Format: Artigo
Sprog:Inglês
Udgivet: 2015
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4688222/
https://ncbi.nlm.nih.gov/pubmed/26497930
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jconrel.2015.10.037
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