Synthesis, Tubulin Assembly, and Antiproliferative Activity Against MCF7 and NCI/ADR-RES Cancer Cells of 10-O-Acetyl-5′-hydroxybutitaxel

A highly efficient kinetic resolution of racemic cis-4-(2-tert-butyldimethylsilyloxy-1,1-dimethyl)ethyl-3-tert-butyldimethylsilyloxy-azetidin-2-one with 7-O-triethylsilylbaccatin III was carried out to furnish 10-O-acetyl-5′-hydroxybutitaxel after removal of the silyl protecting groups. The compound...

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Hlavní autoři: Ge, Haibo, Wang, Jianmei, Kayser, Margaret M., Himes, Richard H., Georg, Gunda I.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2008
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2636847/
https://ncbi.nlm.nih.gov/pubmed/18977659
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2008.10.010
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