Topical Delivery of Muscarinic Receptor Antagonists Prevents and Reverses Peripheral Neuropathy in Female Diabetic Mice

Muscarinic antagonists promote sensory neurite outgrowth in vitro and prevent and/or reverse multiple indices of peripheral neuropathy in rodent models of diabetes, chemotherapy-induced peripheral neuropathy, and HIV protein-induced neuropathy when delivered systemically. We measured plasma concentr...

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發表在:J Pharmacol Exp Ther
Main Authors: Jolivalt, Corinne G., Frizzi, Katie E., Han, May Madi, Mota, Andre J., Guernsey, Lucie S., Kotra, Lakshmi P., Fernyhough, Paul, Calcutt, Nigel A.
格式: Artigo
語言:Inglês
出版: The American Society for Pharmacology and Experimental Therapeutics 2020
主題:
Drug Discovery and Translational Medicine
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC7292964/
https://ncbi.nlm.nih.gov/pubmed/32327528
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.120.265447
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