Self-assembled cGAMP-STINGΔTM signaling complex as a bioinspired platform for cGAMP delivery

The stimulator of interferon (IFN) genes (STING) pathway constitutes a highly important part of immune responses against various cancers and infections. Consequently, administration of STING agonists such as cyclic GMP-AMP (cGAMP) has been identified as a promising approach to target these diseases....

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Bibliographische Detailangaben
Veröffentlicht in:Sci Adv
Hauptverfasser: He, Yanpu, Hong, Celestine, Yan, Emily Z., Fletcher, Samantha J., Zhu, Ge, Yang, Mengdi, Li, Yingzhong, Sun, Xin, Irvine, Darrell J., Li, Jiahe, Hammond, Paula T.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Association for the Advancement of Science 2020
Schlagworte:
Research Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7292616/
https://ncbi.nlm.nih.gov/pubmed/32582856
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.aba7589
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