Zebularine elevates STING expression and enhances cGAMP cancer immunotherapy in mice

DNA methylation abnormality is closely related to tumor occurrence and development. Chemical inhibitors targeting DNA methyltransferase (DNMTis) have been used in treating cancer. However, the impact of DNMTis on antitumor immunity has not been well elucidated. In this study, we show that zebularine...

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Detalhes bibliográficos
Publicado no:Mol Ther
Main Authors: Lai, Junzhong, Fu, Yajuan, Tian, Shuoran, Huang, Shanlu, Luo, Xuan, Lin, Lili, Zhang, Xing, Wang, Hanze, Lin, Zhang, Zhao, Heng, Lin, Shujin, Zhao, Junhong, Xu, Shan, Li, Daliang, Cai, Shaoli, Dong, Luna, Qian, Jing, Liang, Jiadi, Li, Qiumei, Zhang, Yong, Fan, Jiqiang, Balderas, Robert, Chen, Qi
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Gene & Cell Therapy 2021
Assuntos:
Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8116609/
https://ncbi.nlm.nih.gov/pubmed/33571681
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ymthe.2021.02.005
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