Discovery of a Novel cGAMP Competitive Ligand of the Inactive Form of STING

[Image: see text] Drugging large protein pockets is a challenge due to the need for higher molecular weight ligands, which generally possess undesirable physicochemical properties. In this communication, we highlight a strategy leveraging small molecule active site dimers to inhibit the large symmet...

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Bibliografske podrobnosti
izdano v:ACS Med Chem Lett
Main Authors: Siu, Tony, Altman, Michael D., Baltus, Gretchen A., Childers, Matthew, Ellis, J. Michael, Gunaydin, Hakan, Hatch, Harold, Ho, Thu, Jewell, James, Lacey, Brian M., Lesburg, Charles A., Pan, Bo-Sheng, Sauvagnat, Berengere, Schroeder, Gottfried K., Xu, Serena
Format: Artigo
Jezik:Inglês
Izdano: American Chemical Society 2018
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6331172/
https://ncbi.nlm.nih.gov/pubmed/30655953
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.8b00466
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