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Enhancing the Cell-Permeability of Stapled Peptides with a Cyclic Cell-Penetrating Peptide

Stapled peptides recapitulate the binding affinity and specificity of α-helices in proteins, resist proteolytic degradation, and may provide a novel modality against challenging drug targets such as protein-protein interactions. However, most of the stapled peptides have limited cell-permeability or...

תיאור מלא

שמור ב:
מידע ביבליוגרפי
הוצא לאור ב:J Med Chem
Main Authors: Dougherty, Patrick G., Wen, Jin, Pan, Xiaoyan, Koley, Amritendu, Ren, Jian-Guo, Sahni, Ashweta, Basu, Ruchira, Salim, Heba, Appiah Kubi, George, Qian, Ziqing, Pei, Dehua
פורמט: Artigo
שפה:Inglês
יצא לאור: 2019
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC7291828/
https://ncbi.nlm.nih.gov/pubmed/31657556
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.9b00456
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