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Development of a Cell-Permeable Cyclic Peptidyl Inhibitor against the Keap1-Nrf2 Interaction
Macrocyclic peptides have proven highly effective inhibitors of protein–protein interactions, but generally lack cell permeability to access intracellular targets. We show herein that macrocyclic peptides may be rendered highly cell-permeable and biologically active by conjugating with a cyclic cell...
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| Pubblicato in: | J Org Chem |
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| Autori principali: | , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2019
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7288753/ https://ncbi.nlm.nih.gov/pubmed/31609620 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.joc.9b02367 |
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