Expression of Free Fatty Acid Receptor 2 by Dendritic Cells Prevents Their Expression of Interleukin 27 and Is Required for Maintenance of Mucosal Barrier and Immune Response Against Colorectal Tumors in Mice

BACKGROUND & AIMS: Intestinal microbes and their metabolites affect the development of colorectal cancer (CRC). Short-chain fatty acids are metabolites generated by intestinal microbes from dietary fiber. We investigated the mechanisms by which free fatty acid receptor 2 (FFAR2), a receptor for...

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Veröffentlicht in:Gastroenterology
Hauptverfasser: Lavoie, Sydney, Chun, Eunyoung, Bae, Sena, Brennan, Caitlin A., Comeau, Carey Ann Gallini, Lang, Jessica K., Michaud, Monia, Hoveyda, Hamid R., Fraser, Graeme L., Fuller, Miles H., Layden, Brian T., Glickman, Jonathan N., Garrett, Wendy S.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2020
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7291292/
https://ncbi.nlm.nih.gov/pubmed/31917258
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1053/j.gastro.2019.12.027
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