The Crohn’s disease polymorphism, ATG16L1 T300A, alters the gut microbiota and enhances the local Th1/Th17 response

Inflammatory bowel disease (IBD) is driven by dysfunction between host genetics, the microbiota, and immune system. Knowledge gaps remain regarding how IBD genetic risk loci drive gut microbiota changes. The Crohn’s disease risk allele ATG16L1 T300A results in abnormal Paneth cells due to decreased...

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Publicado en:eLife
Main Authors: Lavoie, Sydney, Conway, Kara L, Lassen, Kara G, Jijon, Humberto B, Pan, Hui, Chun, Eunyoung, Michaud, Monia, Lang, Jessica K, Gallini Comeau, Carey Ann, Dreyfuss, Jonathan M, Glickman, Jonathan N, Vlamakis, Hera, Ananthakrishnan, Ashwin, Kostic, Aleksander, Garrett, Wendy S, Xavier, Ramnik J
Formato: Artigo
Idioma:Inglês
Publicado: eLife Sciences Publications, Ltd 2019
Assuntos:
Immunology and Inflammation
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6342529/
https://ncbi.nlm.nih.gov/pubmed/30666959
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.39982
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