Lactulose and Melibiose Inhibit α-Synuclein Aggregation and Up-Regulate Autophagy to Reduce Neuronal Vulnerability

Parkinson’s disease (PD) is a neurodegenerative disease characterized by selective dopaminergic (DAergic) neuronal degeneration in the substantia nigra (SN) and proteinaceous α-synuclein-positive Lewy bodies and Lewy neuritis. As a chemical chaperone to promote protein stability and an autophagy ind...

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Veröffentlicht in:Cells
Hauptverfasser: Chen, Chiung Mei, Lin, Chih-Hsin, Wu, Yih-Ru, Yen, Chien-Yu, Huang, Yu-Ting, Lin, Jia-Lan, Lin, Chung-Yin, Chen, Wan-Ling, Chao, Chih-Ying, Lee-Chen, Guey-Jen, Su, Ming-Tsan, Chang, Kuo-Hsuan
Format: Artigo
Sprache:Inglês
Veröffentlicht: MDPI 2020
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7290909/
https://ncbi.nlm.nih.gov/pubmed/32429337
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cells9051230
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