hiPSC-Derived Cardiomyocyte Model of LQT2 Syndrome Derived from Asymptomatic and Symptomatic Mutation Carriers Reproduces Clinical Differences in Aggregates but Not in Single Cells

Mutations in the HERG gene encoding the potassium ion channel HERG, represent one of the most frequent causes of long QT syndrome type-2 (LQT2). The same genetic mutation frequently presents different clinical phenotypes in the family. Our study aimed to model LQT2 and study functional differences b...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Cells
Main Authors: Shah, Disheet, Prajapati, Chandra, Penttinen, Kirsi, Cherian, Reeja Maria, Koivumäki, Jussi T., Alexanova, Anna, Hyttinen, Jari, Aalto-Setälä, Katriina
Format: Artigo
Jezik:Inglês
Izdano: MDPI 2020
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7290503/
https://ncbi.nlm.nih.gov/pubmed/32392813
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cells9051153
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