hiPSC-Derived Cardiomyocyte Model of LQT2 Syndrome Derived from Asymptomatic and Symptomatic Mutation Carriers Reproduces Clinical Differences in Aggregates but Not in Single Cells

Mutations in the HERG gene encoding the potassium ion channel HERG, represent one of the most frequent causes of long QT syndrome type-2 (LQT2). The same genetic mutation frequently presents different clinical phenotypes in the family. Our study aimed to model LQT2 and study functional differences b...

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Publicado no:Cells
Main Authors: Shah, Disheet, Prajapati, Chandra, Penttinen, Kirsi, Cherian, Reeja Maria, Koivumäki, Jussi T., Alexanova, Anna, Hyttinen, Jari, Aalto-Setälä, Katriina
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7290503/
https://ncbi.nlm.nih.gov/pubmed/32392813
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cells9051153
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