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Progerin Expression Induces Inflammation, Oxidative Stress and Senescence in Human Coronary Endothelial Cells

Hutchinson–Gilford progeria syndrome (HGPS) is a rare premature aging disorder notably characterized by precocious and deadly atherosclerosis. Almost 90% of HGPS patients carry a LMNA p.G608G splice variant that leads to the expression of a permanently farnesylated abnormal form of prelamin-A, refer...

詳細記述

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書誌詳細
出版年:Cells
主要な著者: Bidault, Guillaume, Garcia, Marie, Capeau, Jacqueline, Morichon, Romain, Vigouroux, Corinne, Béréziat, Véronique
フォーマット: Artigo
言語:Inglês
出版事項: MDPI 2020
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC7290406/
https://ncbi.nlm.nih.gov/pubmed/32408587
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cells9051201
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