Influence of Indoleamine-2,3-Dioxygenase and Its Metabolite Kynurenine on γδ T Cell Cytotoxicity against Ductal Pancreatic Adenocarcinoma Cells

Background: Pancreatic ductal adenocarcinoma (PDAC) is a malignant gastrointestinal disease. The enzyme indoleamine-2,3-dioxgenase (IDO) is often overexpressed in PDAC and its downstream metabolite kynurenine has been reported to inhibit T cell activation and proliferation. Since γδ T cells are of h...

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Publicado en:Cells
Autores principales: Jonescheit, Hannah, Oberg, Hans-Heinrich, Gonnermann, Daniel, Hermes, Martin, Sulaj, Vjola, Peters, Christian, Kabelitz, Dieter, Wesch, Daniela
Formato: Artigo
Lenguaje:Inglês
Publicado: MDPI 2020
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7290398/
https://ncbi.nlm.nih.gov/pubmed/32384638
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cells9051140
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